INLYTA is a prescription medicine used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC) when one prior drug treatment for this disease has not worked or has stopped working.
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Ways to help manage certain common side effects
The tips in this section are based on published general guidelines for managing certain side effects common among people with advanced RCC or other cancers.

Not all side effects are manageable. Dose interruptions and/or reductions may be needed during treatment with INLYTA. Be sure to talk to your healthcare professional about any side effects you experience and how they may be managed for you.
Possible side effects
High blood pressure
Diarrhea
Tiredness or feeling weak
Decreased appetite or weight
Nausea or vomiting
Hoarseness
Skin conditions
Constipation
In a clinical study, hypertension occurred as early as 4 days into treatment. On average, this increase was seen within the first month of treatment. INLYTA may cause your blood pressure to rise.

Your doctor should check your blood pressure regularly while you are being treated with INLYTA. If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA. Tell your doctor or nurse if you have high blood pressure or a history of heart disease.

If you have high blood pressure, your healthcare provider’s recommendations may include:
Take antihypertensive medications as prescribed
Recognize signs of potentially dangerous high blood pressure (eg, severe headache, shortness of breath, nosebleeds)
Follow healthy lifestyle choices: regular exercise, weight control, moderate alcohol consumption, sodium restriction

If you are already being treated for your high blood pressure, your doctor may change your blood pressure medicine when you start taking INLTYA. Your doctor may also ask you to track your blood pressure regularly. Follow the advice of your doctor or nurse—talk to them if you have any questions
or concerns.
Diarrhea is more loose or watery stools/bowel movements than usual. If you have these symptoms, call your doctor or nurse. It is important for you and your doctor to try to manage diarrhea as soon as
it begins.


If you experience diarrhea, your healthcare provider’s recommendations may include:
Try yogurt containing probiotics
Eat foods containing soluble fiber
Eat small but frequent meals
Drink fluids such as water, diluted cranberry juice, broth, or decaffeinated tea or coffee
Ask your doctor or nurse if you can be treated with over-the-counter medications
While you are taking INLYTA, you may feel tired or weak. Call your doctor or nurse if you have these symptoms.

If tiredness or feeling weak is a recurring problem, your healthcare provider’s recommendations
may include:
Take short naps and breaks instead of long ones
Eat well and drink plenty of fluids
Take short walks or do light exercise if you feel up to it
Do things that are relaxing, such as listening to music or reading
Stay as active as possible
Try to maintain normal work and social schedules
Ask your doctor if there are over-the-counter or prescription medications that may help you manage your condition
During treatment, you may have less desire to eat. But maintaining good nutrition and a healthy weight are important to your overall health. Protein and calories are even more vital to someone with cancer.

If you have decreased appetite, you can discuss the following diet ideas with your doctor:
Eat several small meals a day—5 or 6 isn’t out of the question
When you are hungry, eat
Enjoy snacks and strive to make them nutritious. Find calories and protein in dried fruits, nuts, cheeses, and even milkshakes
For added protein and calories, it can be a good idea to add gravy, butter, or cheese to your favorite foods
Drink fluids between meals rather than filling up with them during meals
If you are too tired to cook, ask a friend or
family member to make you something. You
may be surprised how many people are willing
to help you
If mouth pain causes you to eat less, consider avoiding spicy foods, eat foods that are soft, or use a straw for liquids
If taste changes cause you to eat less, try cold or frozen foods to minimize taste. Flavor foods with herbs, sugar, or sauces to maximize taste. And keep a clean and healthy mouth by brushing and flossing often
If an upset stomach causes you to eat less, avoid heavy meals, coffee, and alcohol; try sleeping in an upright position; and reduce stress with meditation, yoga, or music
A registered dietitian (RD) may have more ideas to offer you

Ask your doctor if there are over-the-counter or prescription medicines that may help you manage your condition.
It is best to call your doctor or nurse at the first sign of nausea or vomiting. This is especially important if these symptoms keep you from taking your oral medications or keeping them down. Your healthcare provider may prescribe a medicine for these symptoms.

If you experience nausea or vomiting, your healthcare provider’s recommendations may include:
Avoid fatty, fried, spicy, or highly sweet foods
Eat bland foods and drink clear liquids
Eat smaller, more frequent meals
Reduce food aromas and other stimuli with strong odors, and eat food at room temperature to lessen the odor
Listen to soft music, watch a favorite television program, or enjoy the company of others while you eat

If you vomit, start with small amounts of water, broth, or other clear liquids when you are ready to eat again. If that stays down, then try soft foods. Some examples include gelatin, plain cornstarch pudding, yogurt, strained soup, or strained cooked cereal. Slowly work up to eating solid food. Make sure that you do not eat any food that you are allergic to.
Also called dysphonia (dis-phone-ee-uh), this is when you have a weak, rough, or harsh voice.

If you have trouble speaking, your healthcare provider’s recommendations may include:
Drink plenty of water and avoid irritants (eg, dust, smoke, alcohol, industrial chemicals)
Give your voice a break—write things down
Avoid voice strain through shouting or whispering
Skin conditions such as rash, redness, itching, or peeling of skin, are other side effects you may have. You may notice dryness, thickening, calluses, or cracking of the skin on the palms of your hands and soles of your feet. This is called hand-foot syndrome. Some patients may have blisters or a rash. Tell your doctor or nurse if you start to develop skin problems. He or she may give you specific treatments, which may include lotions, moisturizers, or pain medicines.

To help manage the effects of hand-foot syndrome, your healthcare provider’s recommendations may include:
Wear loose cotton clothes
Use sunscreen
Clean hands and feet with lukewarm water and gently pat dry
Apply creams containing lanolin or urea to the hands and feet liberally and often
Avoid tight-fitting shoes and jewelry or rubbing pressure on the hands and feet
Do not shave off blisters
Some people taking INLYTA experience constipation. This has the potential to become a serious side effect. Left untreated, constipation can cause a blockage in your intestines, leading to dehydration and even internal damage.

If you experience constipation, speak to your doctor. He or she may recommend any of
the following:
Drinking more fluids
Taking a stool softener
Changing your dose of INLYTA
Adding fiber to your diet
Increasing physical activity
Getting an enema
Make note of all your side effects and how you’re feeling
Be sure to pay attention to all your side effects. They can be important signs that let you and your doctor know what is happening in your body.

Before starting INLYTA, tell your doctor how you are feeling and about any side effects you have had from other medicines and treatments. As you start taking INLYTA, let your doctor know if you notice any side effects or a change in how you feel. Also tell your doctor if you notice any side effects that are not listed here. Based on your experience, your doctor may change your dose or stop treatment with INLYTA.

Next: If you are having trouble getting INLYTA or need help paying for your medicine, read about access to INLYTA on the next page. Access INLYTA