Side Effect Tips & Videos
Ways to help manage certain common side effects
Not all side effects are manageable. Dose interruptions and/or reductions may be needed during treatment with INLYTA. Be sure to talk to your healthcare professional about any side effects you experience and how they may be managed for you.
Common side effects

Introduction

Introduction

The tips in this section are based on published general guidelines for managing certain side effects common among people with advanced RCC or other cancers.

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High blood pressure

High blood pressure

In a clinical study, hypertension occurred as early as 4 days into treatment. On average, this increase was seen within the first month of treatment. INLYTA may cause your blood pressure to rise.

 

Your doctor should check your blood pressure regularly while you are being treated with INLYTA. If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA. Tell your doctor or nurse if you have high blood pressure or a history of heart disease.

 

If you have high blood pressure, your healthcare provider’s recommendations may include:

  • Take antihypertensive medications as prescribed
  • Recognize signs of potentially dangerous high blood pressure (eg, severe headache, shortness of breath, nosebleeds)
  • Follow healthy lifestyle choices: regular exercise, weight control, moderate alcohol consumption, sodium restriction

If you are already being treated for your high blood pressure, your doctor may change your blood pressure medicine when you start taking INLTYA. Your doctor may also ask you to track your blood pressure regularly. Follow the advice of your doctor or nurse—talk to them if you have any questions or concerns.

 

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Diarrhea

Diarrhea

Diarrhea is more loose or watery stools/bowel movements than usual. If you have these symptoms, call your doctor or nurse. It is important for you and your doctor to try to manage diarrhea as soon as it begins.

 

If you experience diarrhea, your healthcare provider’s recommendations may include:

  • Try yogurt containing probiotics
  • Eat foods containing soluble fiber
  • Eat small but frequent meals
  • Drink fluids such as water, diluted cranberry juice, broth, or decaffeinated tea or coffee
  • Ask your doctor or nurse if you can be treated with over-the-counter medications
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Tiredness or feeling weak

Tiredness or feeling weak

While you are taking INLYTA, you may feel tired or weak. Call your doctor or nurse if you have these symptoms.

 

If tiredness or feeling weak is a recurring problem, your healthcare provider’s recommendations may include:

  • Take short naps and breaks instead of long ones
  • Eat well and drink plenty of fluids
  • Take short walks or do light exercise if you feel up to it
  • Do things that are relaxing, such as listening to music or reading
  • Stay as active as possible
  • Try to maintain normal work and social schedules
  • Ask your doctor if there are over-the-counter or prescription medications that may help you manage your condition
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Decreased appetite or weight

Decreased appetite or weight

During treatment, you may have less desire to eat. But maintaining good nutrition and a healthy weight are important to your overall health. Protein and calories are even more vital to someone with cancer.

 

If you have decreased appetite, you can discuss the following diet ideas with your doctor:

  • Eat several small meals a day—5 or 6 isn’t out of the question
  • When you are hungry, eat
  • Enjoy snacks and strive to make them nutritious. Find calories and protein in dried fruits, nuts, cheeses, and even milkshakes
  • For added protein and calories, it can be a good idea to add gravy, butter, or cheese to your favorite foods
  • Drink fluids between meals rather than filling up with them during meals
  • If you are too tired to cook, ask a friend or family member to make you something. You may be surprised how many people are willing to help you
  • If mouth pain causes you to eat less, consider avoiding spicy foods, eat foods that are soft, or use a straw for liquids
  • If taste changes cause you to eat less, try cold or frozen foods to minimize taste. Flavor foods with herbs, sugar, or sauces to maximize taste. And keep a clean and healthy mouth by brushing and flossing often
  • If an upset stomach causes you to eat less, avoid heavy meals, coffee, and alcohol; try sleeping in an upright position; and reduce stress with meditation, yoga, or music
  • A registered dietitian (RD) may have more ideas to offer you

Ask your doctor if there are over-the-counter or prescription medicines that may help you manage your condition.

 

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Nausea or vomiting

Nausea or vomiting

It is best to call your doctor or nurse at the first sign of nausea or vomiting. This is especially important if these symptoms keep you from taking your oral medications or keeping them down. Your healthcare provider may prescribe a medicine for these symptoms.

 

If you experience nausea or vomiting, your healthcare provider’s recommendations may include:

  • Avoid fatty, fried, spicy, or highly sweet foods
  • Eat bland foods and drink clear liquids
  • Eat smaller, more frequent meals
  • Reduce food aromas and other stimuli with strong odors, and eat food at room temperature to lessen the odor
  • Listen to soft music, watch a favorite television program, or enjoy the company of others while you eat

If you vomit, start with small amounts of water, broth, or other clear liquids when you are ready to eat again. If that stays down, then try soft foods. Some examples include gelatin, plain cornstarch pudding, yogurt, strained soup, or strained cooked cereal. Slowly work up to eating solid food. Make sure that you do not eat any food that you are allergic to.

 

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Hoarseness

Hoarseness

Also called dysphonia (dis-phone-ee-uh), this is when you have a weak, rough, or harsh voice.

 

If you have trouble speaking, your healthcare provider’s recommendations may include:

  • Drink plenty of water and avoid irritants (eg, dust, smoke, alcohol, industrial chemicals)
  • Give your voice a break—write things down
  • Avoid voice strain through shouting or whispering
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Skin conditions

Skin conditions

Skin conditions such as rash, redness, or itching or peeling of skin, are other side effects you may have. You may notice dryness, thickening, calluses, or cracking of the skin on the palms of your hands and soles of your feet. This is called hand-foot syndrome. Some patients may have blisters or a rash. Tell your doctor or nurse if you start to develop skin problems. He or she may give you specific treatments, which may include lotions, moisturizers, or pain medicines.

 

To help manage the effects of hand-foot syndrome, your healthcare provider’s recommendations may include:

  • Wear loose cotton clothes
  • Use sunscreen
  • Clean hands and feet with lukewarm water and gently pat dry
  • Apply creams containing lanolin or urea to the hands and feet liberally and often
  • Avoid tight-fitting shoes and jewelry or rubbing pressure on the hands and feet
  • Do not shave off blisters
Hand-foot syndrome

Dryness, thickening, or cracking of the skin on the palms of the hands and soles of the feet. It can sometimes include blisters or a rash.

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Constipation

Constipation

Some people taking INLYTA experience constipation. This has the potential to become a serious side effect. Left untreated, constipation can cause a blockage in your intestines, leading to dehydration and even internal damage.

 

If you experience constipation, speak to your doctor. He or she may recommend any of the following:

  • Drinking more fluids
  • Taking a stool softener
  • Changing your dose of INLYTA
  • Adding fiber to your diet
  • Increasing physical activity
  • Getting an enema
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INLYTA is a prescription medicine used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC) when one prior drug treatment for this disease has not worked or has stopped working.

IMPORTANT SAFETY INFORMATION Full Prescribing Information and Patient Information

Before you take INLYTA, tell your doctor if you:

  • Have high blood pressure
  • Have thyroid problems
  • Have liver problems
  • Have a history of blood clots in your veins or arteries (types of blood vessels), including stroke, heart attack, or change in vision
  • Have any bleeding problems
  • Have a history of heart failure
  • Have an unhealed wound
  • Plan to have surgery. You should stop taking INLYTA at least 24 hours before planned surgery
  • Have any other medical conditions
 

Tell your doctor and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. INLYTA and certain other medicines can affect each other causing serious side effects. Talk with your doctor before you start taking any new medicine.

Especially tell your doctor if you take dexamethasone, bosentan, modafinil, St. John's wort (Hypericum perforatum), or medicine for asthma, tuberculosis, seizures, bacterial infections, fungal infections, depression, or HIV/AIDS.

Do not drink grapefruit juice or eat grapefruit.

Pregnancy and breastfeeding. Women should not take INLYTA if they are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed. Taking INLYTA during pregnancy can cause the death of an unborn baby or birth defects. Both men and women taking INLYTA should use effective birth control during treatment with INLYTA. Talk to your doctor about birth control methods, or if you are pregnant or plan to become pregnant.

INLYTA may cause serious side effects, including:

High blood pressure (hypertension). In a clinical study, hypertension occurred as early as 4 days into treatment. On average, this increase was seen within the first month of treatment. Your doctor should check your blood pressure regularly during treatment with INLYTA. If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA.

Problem with blood clots in your veins or arteries. Because this can be serious and sometimes lead to death, get emergency help and call your doctor if you get any of the following symptoms:

  • Chest pain or pressure
  • Pain in your arms, back, neck or jaw
  • Shortness of breath
  • Numbness or weakness on one side of your body
  • Trouble talking
  • Headache
  • Vision changes

Bleeding. INLYTA can cause bleeding which can be serious, and sometimes lead to death. Call your doctor right away or get medical help if you develop any of the following signs or symptoms:

  • Unexpected bleeding or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Menstrual bleeding or vaginal bleeding that is heavier than normal
    • Bleeding that is severe or you cannot control
    • Pink or brown urine
    • Red or black stools (looks like tar)
    • Bruises that happen without a known cause or get larger
    • Cough up blood or blood clots
    • Vomit blood or your vomit looks like "coffee grounds"
  • Unexpected pain, swelling, or joint pain
  • Headaches, feeling dizzy or weak

Heart failure.Your doctor should check for signs or symptoms of heart failure regularly during treatment with INLYTA. Heart failure can be serious and can sometimes lead to death. Tell your doctor if you have any of the following symptoms during your treatment with INLYTA:

  • Tiredness
  • Swelling of your stomach area (abdomen), legs, or ankles
  • Shortness of breath
  • Protruding neck veins

Tear in your stomach or intestinal wall (perforation). Because this can be serious and sometimes lead to death, get medical help right away if you get the following symptoms:

  • Severe stomach (abdominal) pain or stomach pain that does not go away
  • Vomit blood
  • Red or black stools

Thyroid gland problems. Your doctor should do blood tests to check your thyroid gland function before and during your treatment with INLYTA. Tell your doctor if you have any of the following symptoms during your treatment with INLYTA:

  • Tiredness that worsens or that does not go away
  • Feeling hot or cold
  • Your voice deepens
  • Weight gain or weight loss
  • Hair loss
  • Muscle cramps and aches

Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome (RPLS) can happen while taking INLYTA. Call your doctor right away if you get:

  • Headache
  • Seizures
  • Weakness
  • Confusion
  • High blood pressure
  • Blindness or change in vision
  • Problems thinking

Increased protein in your urine. Your doctor should check your urine for protein before and during your treatment with INLYTA. If you develop protein in your urine, your doctor may decrease your dose of INLYTA or stop your treatment.

Change in liver function. Your doctor should do blood tests before and during your treatment with INLYTA to check your liver function.

The most common side effects of INLYTA include:

  • Diarrhea (frequent or loose bowel movements)
  • High blood pressure
  • Tiredness or feeling weak
  • Decreased appetite
  • Nausea
  • Hoarseness
  • Rash, redness, itching or peeling of your skin on your hands or feet
  • Decreased weight
  • Vomiting
  • Constipation

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of INLYTA. For more information, ask your doctor or pharmacist.

INDICATION

INLYTA is a prescription medicine used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC) when one prior drug treatment for this disease has not worked or has stopped working.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see full Prescribing Information and Patient Information, including a complete discussion of the risks of INLYTA.


 
Scroll for Important Safety Information and Indication

Important safety information

Before you take INLYTA, tell your doctor if you:

  • Have high blood pressure
  • Have thyroid problems
  • Have liver problems
  • Have a history of blood clots in your veins or arteries (types of blood vessels), including stroke, heart attack, or change in vision
  • Have any bleeding problems
  • Have a history of heart failure
  • Have an unhealed wound
  • Plan to have surgery. You should stop taking INLYTA at least 24 hours before planned surgery
  • Have any other medical conditions

Tell your doctor and pharmacist about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. INLYTA and certain other medicines can affect each other causing serious side effects. Talk with your doctor before you start taking any new medicine. Especially tell your doctor if you take dexamethasone, bosentan, modafinil, St. John's wort (Hypericum perforatum), or medicine for asthma, tuberculosis, seizures, bacterial infections, fungal infections, depression, or HIV/AIDS.

Do not drink grapefruit juice or eat grapefruit.

Pregnancy and breastfeeding. Women should not take INLYTA if they are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed. Taking INLYTA during pregnancy can cause death of an unborn baby or birth defects. Both men and women taking INLYTA should use effective birth control during treatment with INLYTA. Talk to your doctor about birth control methods, or if you are pregnant or plan to become pregnant.

INLYTA may cause serious side effects, including:

High blood pressure (hypertension). In a clinical study, hypertension occurred as early as 4 days into treatment. On average, this increase was seen within the first month of treatment. Your doctor should check your blood pressure regularly during treatment with INLYTA.
If you develop blood pressure problems, your doctor may prescribe medicine to treat your high blood pressure, lower your dose, or stop your treatment with INLYTA.

Problem with blood clots in your veins or arteries. Because this can be serious and sometimes lead to death, get emergency help and call your doctor if you get any of the following symptoms:

  • Chest pain or pressure
  • Pain in your arms, back, neck or jaw
  • Shortness of breath
  • Numbness or weakness on one side of your body
  • Trouble talking
  • Headache
  • Vision changes

Bleeding. INLYTA can cause bleeding which can be serious, and sometimes lead to death. Call your doctor right away or get medical help if you develop any of the following signs or symptoms:

  • Unexpected bleeding or bleeding that lasts a long time, such as:
    • Unusual bleeding from the gums
    • Menstrual bleeding or vaginal bleeding that is heavier than normal
    • Bleeding that is severe or you cannot control
    • Pink or brown urine
    • Red or black stools (looks like tar)
    • Bruises that happen without a known cause or get larger
    • Cough up blood or blood clots
    • Vomit blood or your vomit looks like "coffee grounds"
  • Unexpected pain, swelling, or joint pain
  • Headaches, feeling dizzy or weak

Heart failure. Your doctor should check for signs or symptoms of heart failure regularly during treatment with INLYTA. Heart failure can be serious and can sometimes lead to death. Tell your doctor if you have any of the following symptoms during your treatment with INLYTA:

  • Tiredness
  • Swelling of your stomach area (abdomen), legs, or ankles
  • Shortness of breath
  • Protruding neck veins

Tear in your stomach or intestinal wall (perforation). Because this can be serious and sometimes lead to death, get medical help right away if you get the following symptoms:

  • Severe stomach (abdominal) pain or stomach pain that does not go away
  • Vomit blood
  • Red or black stools

Thyroid gland problems. Your doctor should do blood tests to check your thyroid gland function before and during your treatment with INLYTA. Tell your doctor if you have any of the following symptoms during your treatment with INLYTA:

  • Tiredness that worsens or that does not go away
  • Feeling hot or cold
  • Your voice deepens
  • Weight gain or weight loss
  • Hair loss
  • Muscle cramps and aches

Reversible Posterior Leukoencephalopathy Syndrome (RPLS). A condition called reversible posterior leukoencephalopathy syndrome (RPLS) can happen while taking INLYTA. Call your doctor right away if you get:

  • Headache
  • Seizures
  • Weakness
  • Confusion
  • High blood pressure
  • Blindness or change in vision
  • Problems thinking

Increased protein in your urine. Your doctor should check your urine for protein before and during your treatment with INLYTA. If you develop protein in your urine, your doctor may decrease your dose of INLYTA or stop your treatment.

Change in liver function. Your doctor should do blood tests before and during your treatment with INLYTA to check your liver function.

The most common side effects of INLYTA include:

  • Diarrhea (frequent or loose bowel movements)
  • High blood pressure
  • Tiredness or feeling weak
  • Decreased appetite
  • Nausea
  • Hoarseness
  • Rash, redness, itching or peeling of your skin on your hands or feet
  • Decreased weight
  • Vomiting
  • Constipation

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of INLYTA. For more information, ask your doctor or pharmacist.

INDICATION

INLYTA is a prescription medicine used to treat advanced kidney cancer (advanced renal cell carcinoma or RCC) when one prior drug treatment for this disease has not worked or has stopped working.

Please see full Prescribing Information and Patient Information, including a complete discussion of the risks of INLYTA.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.